在口服肠道向蛋白质输送中的三明治类纳米粒子粒子连续相的层次组装机制
Wen-Xuan Hu1, Chang-Sen Jin1, Si-Lin Li1
1College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, PR China.
Food chemistry
|July 3, 2025
概括
研究人员使用氧化粉纳米晶和奇托开发了新的三层颗粒,用于向酶输送. 这些颗粒显示出稳定,结肠特异性口服蛋白质输送的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 纳米技术纳米技术
背景情况:
- 层层组装 (LbL) 对于开发先进材料至关重要.
- 了解材料相互作用和相位状态是控制组装的关键.
- 有针对性的药物输送系统需要精确控制粒子形态和释放动力学.
研究的目的:
- 为了研究氧化粉纳米晶体 (OSNC) 和四级基 (QAC) 的LbL组装行为.
- 开发用于酶 (LYS) 目标和持续释放的三层颗粒.
- 为了评估这些颗粒在口服蛋白质/多类配送中的潜力.
主要方法:
- 使用LbL组件,使用OSNC作为颗粒物阶段和QAC作为连续阶段.
- 进行了热力学结合研究以分析材料相互作用 (OSNC-LYS,OSNC-QAC).
- 在不同的条件下,具有粒子形态,分散性和LYS保留的特征.
主要成果:
- 确定了强大的OSNC-QAC相互作用和较弱的OSNC-LYS相互作用,影响LYS保留.
- 观察到"类似三明治"的形态,由状OSNC促进,增强分散.
- 在较低的LYS负载和在较高的LYS水平上聚合时,证明了增强的分散性.
- 实现了针对结肠的LYS输送,并保持了生物活性,pH敏感性和稳定性.
结论:
- 开发的三层颗粒能够有效地向结肠向输送lyszyme.
- 由材料相互作用驱动的组装机制允许可调节的粒子特性.
- 这些发现突显了OSNC-QAC系统在口服蛋白质和多递送方面的潜力.
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