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微塑料与双A的相互作用:吸附,脱附和体外生物效应

Astrid Saraceni¹, Valentina Schiavo², Barbara Mognetti³

¹Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123, Turin, Italy.

The Science of the total environment

|July 3, 2025

概括

微塑料 (MP) 的表面化学影响有毒性和污染物运输. 氧化MP更有毒,更好地携带双A (BPA),但没有观察到与BPA吸收的MP有协同效应.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
材料科学材料科学材料科学

背景情况:

微塑料 (MP) 污染对环境和健康构成风险,MP可能会吸附诸如双A (BPA) 等危险化学物质.
了解MP污染物相互作用对于评估生态和人类健康影响至关重要.

研究的目的:

对各种细胞类型的原始和功能化MPs的毒性进行调查.
量化BPA在MPs上的吸附和脱吸动态.
为了评估BPA吸收的MPs的生物效应.

主要方法:

预脂细胞,肝细胞,神经元和内皮细胞暴露于原始和碳素功能化聚烯MPs (PS-MPs).
使用HPLC-MS/MS.评估细胞活力,脂质积累和BPA吸附/溶解.
分析原始的PS-MPs和含有BPA和不含BPA的炭基功能化PS-MPs (COOH-MPs).

主要成果:

高度的COOH-MPs诱导了神经元和内皮细胞的毒性,并改变了脂肪细胞的分化.
与原始MP相比,COOH-MP的BPA吸附率 (29%) 和脱附率 (45%) 较高 (23%的吸附率,13%的脱附率).
当细胞暴露于BPA吸收的MPs时,没有观察到协同作用的毒性作用.

结论:

聚烯表面化学,特别是氧化,显著影响了聚烯的毒性和它们作为BPA等污染物的载体的作用.
在生理条件下,氧化MP在吸附和释放BPA方面更有效.
评估污染物吸附于MPs对于理解其作为环境污染物载体的作用至关重要.

关键词:

双 A 是一种双.细胞毒性细胞毒性在HPLC-tandemMSMS中使用.微塑料是一种微塑料.聚乙烯是一种聚乙烯.吸附吸附方式吸附吸附方式

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