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在IVB阶段的无塑性甲状腺癌前期多式疗法后,辅助勃利祖马布
Maria E Cabanillas1, Naifa L Busaidy1, G Brandon Gunn2
1Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, Texas, USA.
辅助 pembrolizumab 显著改善了 IVB 阶段的甲状腺腺癌 (ATC) 患者的无进展生存率和整体生存率. 这种免疫疗法策略在预防复发和延长多式疗法后的寿命方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 甲状腺癌研究研究
背景情况:
- 无塑性甲状腺癌 (ATC) 是一种高度攻击性的恶性瘤,在历史上预后不佳.
- 目前对局部区域IVBATC的标准护理包括多模式治疗,然后观察.
- 需要新的治疗策略来改善ATC患者的治疗结果.
研究的目的:
- 为了评估辅助 pembrolizumab 的疗效和安全性,在IVB 阶段的甲状腺癌患者.
- 为了比较接受辅助 pembrolizumab 和对照组的患者之间的无进展生存 (PFS),复发率和整体生存 (OS).
主要方法:
- 这项研究结合了前性2期试验和IVB期ATC患者的回顾性队列,这些患者接受了多式疗法和辅助 pembrolizumab.
- 患者在辐射后6周内接受了辅助 pembrolizumab.
- 一个年龄和治疗匹配的对照组接受了多式疗法,没有辅助剂pembrolizumab.
主要成果:
- 在辅助 pembrolizumab 组中没有达到 PFS 的中位数,而在对照组中为 5.4 个月 (p=0.006).
- 辅助手臂没有达到中位 OS,而对照手臂的 31 个月 (p=0.009).
- 辅助手臂的所有患者在1年和2年的随访中存活下来,而对照手臂的患者分别为80%和52%.
结论:
- 辅助布罗利祖马布表明,它是一种安全有效的策略,可以预防IVB阶段的ATC患者的复发并延长他们的生存时间.
- 布罗利祖马布可能在治疗晚期形甲状腺癌方面取得了重大进展.
- 需要进一步的证实性研究来验证这些有希望的发现.
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