使用,急性并发症和与前列腺癌放射治疗的直肠间隔相关的治疗延迟
Jack C Millot1, Adithya Balasubramanian2, Lauren Chew1
1Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Urology
|July 3, 2025
概括
在前列腺癌辐射中,直肠水凝间隔器的使用正在增加,特别是在SBRT. 并发症虽然很少见,但可能会延迟放射治疗的开始.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医疗器械 医疗器械
背景情况:
- 直肠水凝间隔器用于减少前列腺癌治疗期间直肠的辐射剂量.
- 了解间隔器放置并发症及其对治疗的影响对于患者管理至关重要.
研究的目的:
- 为了调查与美国直肠水凝间隔器相关的利用,并发症和辐射治疗延迟.
- 分析间隔器放置并发症对辐射疗法启动时间的影响.
主要方法:
- 对前列腺癌患者的Merative MarketScan数据库 (2016-2021) 的回顾性分析.
- 识别间隔器的放置,辐射,生殖尿道/胃肠道并发症和干预措施.
- 使用考克斯的比例危险模型来评估并发症对辐射时间的影响.
主要成果:
- 在前列腺癌辐射患者 (2016-2021) 中,间隔器的使用量从0.5%增加到25.7%,在2021年SBRT患者中达到50%.
- 在放射治疗前,6.4%的患者出现并发症,主要是泌尿器官 (5.2%) 和胃肠道 (1.2%).
- 并发症显著降低了开始放射治疗的风险 (HR 0.75,P < .001).
结论:
- 直肠水凝间隔器的使用变得越来越普遍,特别是在前列腺癌中用于SBRT.
- 虽然不常见,但与间隔器放置相关的并发症可能导致启动放射治疗的延迟.
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