应激适应反应在多发性硬化症中的作用
Evangelia Zapanti1, Alexandros Dermentzoglou2, Paraskevi Kazakou3
1Endocrine Unit and Diabetes Centre, Alexandra Hospital, Athens, Greece.
Frontiers in neuroendocrinology
|July 3, 2025
概括
应激适应反应可能通过破坏免疫功能和荷尔蒙释放来恶化多发性硬化症 (MS). 本综述探讨了压力与多发性硬化症恶化之间的联系,强调了患者观察到的神经免疫变化.
科学领域:
- 神经免疫学 神经免疫学
- 内分泌学 在内分泌学.
- 神经系统疾病的病理生理学.
背景情况:
- 多发性硬化症 (MS) 是一种主要的自身免疫性炎症性神经疾病,其特征是中枢神经系统 (CNS) 中的脱髓化病变.
- 病原发生涉及遗传和环境因素,导致免疫介导的髓和轴突损伤,以及质痕.
- 应激适应反应可能通过荷尔蒙和神经释放加速MS恶化,导致免疫调节失调和改变细胞因子配置.
研究的目的:
- 批判性地审查应激适应反应在多发性硬化症的表现和恶化中的作用.
- 阐明压力适应反应与MS生理病理学之间的不清楚联系.
- 检查MS患者在压力下的神经免疫学发现.
主要方法:
- 对有关应激反应系统和多发性硬化症的现有文献进行批判性审查.
- 分析神经免疫学研究,研究MS患者在压力下的细胞因子和淋巴细胞.
- 在MS中检查下丘脑-垂体-上腺轴,交感神经系统和多巴胺系统的调节障碍.
主要成果:
- 应激适应反应可能导致免疫失调和改变细胞因子的产生,可能会加剧MS.
- 神经免疫学研究表明,MS患者经历压力时,细胞因子和淋巴细胞发生显著变化.
- 在MS患者中观察到关键压力系统组件的失调,包括下丘脑-垂体-上腺轴,交感神经系统和多巴胺系统.
结论:
- 应激适应反应在多发性硬化症的表现和恶化中起着重要作用.
- 了解压力的神经免疫影响对于管理MS至关重要.
- 需要进一步的研究来澄清精确的机制,将压力与MS病理和临床结果联系起来.
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