皮克林乳液凝稳定了沙丁鱼蛋白/孔雅克葡萄康曼南复合体,提供阿斯塔桑来缓解炎症性肠病
Jiayue Liang1, Jiale Ma1, Yu Sun1
1State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Dalian Key Laboratory for Precision Nutrition, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
新的沙丁鱼蛋白和康杰克葡萄甘皮克林乳液凝有效地为炎症性肠病 (IBD) 干预提供阿斯塔山丁. 这些凝增强了小鼠的阿斯塔山丁生物可用性和肠道健康.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物材料工程 生物材料工程
- 营养药和功能性食品 营养药和功能性食品
背景情况:
- 阿斯塔克桑丁 (AXT) 显示在炎症性肠病 (IBD) 中具有治疗潜力,但具有不良的溶解性和低生物可用性.
- 有限的AXT生物可用性阻碍了其在功能性食品中用于IBD管理的应用.
- 开发有效的输送系统对于利用AXT的抗炎性质至关重要.
研究的目的:
- 开发鱼蛋白 (SDP) /果糖甘 (KGM) 稳定皮克林乳液凝 (SKEGs) 来增强阿斯塔克桑 (AXT) 输送.
- 研究用于AXT封装的SKEGs的物理化学特性和稳定性.
- 在IBD的体内模型中评估AXT装载SKEGs的疗效.
主要方法:
- 使用键和疏水性相互作用识别分析了SDP和KGM的相互作用.
- 皮克林乳液的特点是微观结构,滴滴大小以及在各种条件下 (热量,离子强度,储存) 的稳定性.
- 在紫外线照射和加热后评估了AXT保留;模拟消化和体内IBD小鼠模型被用于评估生物可用性和治疗效果.
主要成果:
- SDP / KGM 相互作用 (结合,疏水) 改善了界面吸附和可湿性,在 1.2% KGM 处具有最佳的微观结构.
- SKEGs表现出对热,离子强度和长期储存的增强稳定性,与自由AXT相比,AXT保留率更高.
- 在体内研究表明,AXT载的SKEG减轻了IBD症状,保护了结肠完整性,调节了炎症因素,恢复了紧结蛋白,改善了肠道微生物群组成.
结论:
- SKEGs提供了一种新且有效的策略,用于提高阿斯塔山丁的生物可访问性和生物可用性.
- 这种输送系统有望用于功能性食品应用,用于管理炎症性肠病.
- 该研究强调了利用像沙丁鱼蛋白一样的海洋资源的潜力,用于先进的营养药物输送系统.
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