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化学抗原受体T细胞治疗的并发症

Gregory Chang¹, Brian Cameron¹

¹MD Anderson, Department. of Emergency Medicine. PO Box 301402, Unit 1468, Houston, TX 77230-1402, USA.

Emergency medicine clinics of North America

|July 3, 2025

概括

化学抗原受体T细胞疗法提供了癌症治疗的进步,但存在风险. 意识到潜在的副作用,包括细胞因子释放综合征和神经毒性,对于患者管理至关重要.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

化学抗原受体 (CAR) T细胞疗法代表了癌症治疗的重大进展.
虽然有效,但CAR T细胞疗法与一系列潜在的不良事件有关.
了解这些毒性对于安全的临床应用至关重要.

研究的目的:

提供与CAR T细胞治疗相关的潜在副作用的全面概述.
强调识别和管理常见和不常见的毒性的重要性.
强调在接受或接受过CAR T细胞治疗的患者中需要高怀疑指数.

主要方法:

审查与CAR T细胞治疗相关的已知并发症.
将毒性分类为已知和其他潜在的不良事件.
强调对患者监测的临床警.

主要成果:

细胞因子释放综合征 (CRS) 和免疫效应细胞相关的神经毒性综合征 (ICANS) 是已知的毒性.
其他潜在的并发症包括B细胞和T细胞无形成症/低球蛋白血症,机会性感染,凝血病,移植与宿主综合征,免疫效应细胞相关的血细胞淋巴细胞样性综合征 (HLH样性综合征) 和瘤外瘤毒性.
这些不良事件需要仔细监测和管理.

结论:

用CAR T细胞治疗需要对一系列潜在副作用进行警监测.
早期识别和及时管理毒性对于患者安全和治疗成功至关重要.
对于临床医生管理接受CAR T细胞治疗的患者来说,高度的怀疑指数至关重要.

关键词:

亚普拉西亚 (aplasia) 是一种表现不良的现象.卡特卡特卡特克雷斯克雷斯是什么意思在CRS中,您可以使用CRS.化学抗原受体毒性化学抗原受体毒性凝血病是一种凝血病.细胞因子释放综合征细胞因子释放综合征细胞衰竭症 (cytopenia) 是一个严重的疾病.在GVHD中,GVHD是指GVHD 移植与宿主之间的关系血细胞性淋巴细胞细胞分裂.这种情况是Hypogammaglobulinemia.在ICANS中,我们可以看到ICANS.免疫效应细胞是免疫效应细胞.神经毒性神经毒性有毒性有毒性

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