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针对全身定量成像的PET/CT性能要求的标准化:一项国际建议
John J Sunderland1, Ronald Boellaard2,3, John C Dickson4
1Department of Radiology, University of Iowa, Iowa City, Iowa; john-sunderland@uiowa.edu.
概括
提出了一种新的标准化PET扫描仪验证方法,以提高临床试验的效率和降低临床试验成本. 这种方法协调了幻影要求,数据分析和接受标准,以获得一致的PET扫描仪性能.
科学领域:
- 核医学是一种核医学.
- 医学成像物理 医学成像物理
- 临床试验方法论 临床试验方法论
背景情况:
- 目前的 pozitron发射断层扫描 (PET) 扫描仪验证缺乏标准化,导致效率低下和临床试验的重复测试.
- 现有的EARL,SNMMI CTN和ANZSNM的验证计划提供了协调的机会.
研究的目的:
- 为临床试验提出一个标准化的PET扫描仪验证范式.
- 在临床环境中确定PET扫描仪的关键定量性能特征.
主要方法:
- 审查了现有的PET扫描仪验证程序 (EARL,SNMMI CTN,ANZSNM),以确定共同点和差异.
- 确定了与临床试验相关的PET定量性能的关键标准.
- 推标准化基于幻影的测量方法,用于校准和回收系数.
主要成果:
- 开发了标准化幻影要求,采集协议,重建方法,分析技术和接受标准.
- 提出了一个基于放射性核素特异性校准和协调回收系数性能的验证计划.
- 建议每季度进行18F校准验证 (准确率±5%) 和每年对其他放射性核素进行验证 (准确率±10%).
结论:
- 为临床试验提出了一种国际标准化的PET扫描仪验证范式.
- 该系统的采用将提高PET扫描仪验证的效率,稳定性和可靠性.
- 预计实施将降低成本,并消除临床试验中的冗余测试.
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