饮食干预药物复杂的形成石头的儿童与肠道高氧化尿的饮食干预
William DeFoor1, Joonsue Lee1, Marion Schulte1
1Divisions of Pediatric Urology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Journal of pediatric urology
|July 3, 2025
概括
饮食干预可能会在患有结石的医疗复杂儿童中改变尿氧酸. 虽然初步结果显示了较低氧沙酸盐的趋势,但需要对更多患者进行进一步的研究来确认疗效.
科学领域:
- 儿科脏病学 儿科脏病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 营养科学 营养科学
背景情况:
- 在医学上复杂,有神经认知障碍的非行医儿童有高风险患结石病.
- 在经常形成石头的儿童中观察到尿氧酸盐水平升高,这些儿童食用的是基于大豆的配方.
研究的目的:
- 确定是否有针对性的饮食干预可以减少尿路结石风险概况在这个脆弱的儿科群体.
- 评估饮食改变对非行医儿童尿氧酸盐水平的影响神经认知障碍.
主要方法:
- 对脑和/或严重发育迟缓的非健行患者进行了回顾性队列研究.
- 进行了基线24小时尿液收集,将患者分为高氧化酸盐和低氧化酸盐饮食.
- 高氧化酸盐饮食的患者被转换为低氧化酸盐饮食,并进行了多次尿样评估.
主要成果:
- 十四名患者符合纳入标准;四名患者在基线高氧酸盐饮食中 (中位数为67 mg/m2/day).
- 在饮食修改后,尿液中氧酸盐下降到31 mg/m2/day,尽管在统计学上不显著 (p=0.1).
- 和酸盐指数保持不变.
结论:
- 这项试点研究表明,通过饮食改变,可以在高风险儿童中改变尿液中氧化酸盐的分泌.
- 需要对更大的队列进行进一步的研究,以确认饮食中氧化酸盐的限制是否会减少结石的形成.
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