马激活传播反映了肌缩性侧面硬化症的疾病活性
Michael Trubshaw1, Katie Yoganathan1, Chetan Gohil2
1Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 7JX, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
概括
基于任务的磁大脑扫描显示,在肌缩性侧面硬化症 (ALS) 患者中,马激活传播增加. 这一测量与疾病进展相关,表明其作为ALS生物标志物的潜力.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 运动系统障碍 运动系统障碍
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种影响运动神经元的神经退行性疾病.
- 需要在ALS中发现大脑运动系统功能障碍的非侵入性生物标志物.
- 基于任务的磁脑电图 (tMEG) 在运动任务期间测量皮质活动.
研究的目的:
- 在ALS中使用tMEG调查大脑运动系统功能障碍.
- 评估马激活扩散 (GAS) 作为ALS的潜在生物标志物.
主要方法:
- 在42名ALS患者和33名健康对照者 (HC) 的手握练习中进行了tMEG.
- 马激活扩散 (GAS) 是通过每100 ms计数激活的大脑区域来量化.
- 在ALS患者和HC患者之间进行了统计比较.
主要成果:
- 在ALS患者和HC患者之间没有观察到抓握强度的显著差异.
- 与HC相比,ALS组的GAS显著增加 (p < 0.001).与HC相比,ALS组的GAS显著增加 (p < 0.001).
- 增加的GAS与ALSFRS-R进展率和精细运动损伤率呈正相关性.
结论:
- 关联ALS与马频率激活的区域传播显著增加.
- 马激活传播的程度在疾病进展较快的个体中更大.
- 区域性马活动传播显示出作为ALS实验药物读数的潜力.
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