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Updated: Jul 3, 2026

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对mRNA-1345RSV疫苗疗效临床试验的免疫相关分析

Chong Ma1, Jiejun Du1, Lan Lan1

  • 1Moderna Inc, Cambridge, MA, USA.

Nature communications
|July 3, 2025
PubMed
概括

在接种疫苗后29天测量的中和抗体和预注射IgG是对RSV下呼吸道疾病和老年人急性呼吸道疾病的保护的可靠相关物. 这些免疫标志物支持疫苗的疗效.

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Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...