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Updated: Sep 17, 2025

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
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Published on: May 22, 2019

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与普拉德-威利综合征相关的EHMT2-介导基因组印记的机制

Sung Eun Wang1,2, Yubao Cheng1, Jaechul Lim3,4

  • 1Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.

Nature communications
|July 3, 2025
PubMed
概括

来自母亲染色体的普拉德-威利综合征 (PWS) 基因表达被EHMT2.2沉默. 这项研究揭示了一种非编码RNA,它招募了EHMT2,维持了PWS的印记,并提供了新的治疗点.

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