皮层宏观和微观结构的变化在孤立的快速眼球运动睡眠行为障碍
Jèssica Pardo1,2, Ignacio Roura1,2, Victor Montal3,4
1Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
NPJ Parkinson's disease
|July 3, 2025
概括
皮层平均扩散度 (cMD) 在孤立的REM睡眠行为障碍 (iRBD) 中显示了早期皮层变化,这是勒维体疾病的前体. 这种成像标记可能比皮质厚度更敏感,用于检测这些神经退行变化.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 睡眠医学 睡眠医学
背景情况:
- 孤立REM睡眠行为障碍 (iRBD) 是莱维体疾病的前兆阶段.
- 皮层微结构变化与神经退行有关.
- 皮质平均扩散度 (cMD) 和皮质厚度 (CTh) 是潜在的成像生物标志物,但它们在iRBD中的作用尚未研究.
研究的目的:
- 在iRBD患者中调查cMD和CTh.
- 探索cMD,CTh和iRBD中的临床/神经心理特征之间的关系.
- 为了确定cMD是否是一个敏感的生物标志物,用于早期皮质变化在前期的勒维体疾病.
主要方法:
- 扩散张力成像 (DTI) 用于测量cMD.
- 使用结构MRI测量CTh.
- 三十六名iRBD患者和29名健康对照 (HC) 被评估与临床和认知措施的关联.
主要成果:
- 与HC (科恩d > 0.5) 相比,患有iRBD的患者在面部和尾部皮质区域显著增加了cMD.
- 皮层稀释仅在iRBD患者的尾部区域观察到.
- 较高的cMD与较长的iRBD持续时间,较晚的疾病发作,较高的MDS-UPDRS III分数,冷漠和较差的Grooved Pegboard和Symbol-Digit Modality测试的表现相关.
结论:
- cMD在iRBD患者的皮质中升高,表明早期的微观结构变化.
- cMD似乎是一个比CTh更敏感的生物标志物,用于检测早期皮质变化在前期的勒维体疾病.
- cMD作为一种有价值的成像生物标志物,有望用于识别患有神经退行症高风险的个体.
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