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Updated: Sep 17, 2025

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胰腺β细胞在现场通过ALK3激动剂THR-12323再生

Silvia Álvarez-Cubela1,2, Isabella D Altilio1, Mayur Doke1

  • 1Diabetes Research Institute, University of Miami Miller School of Medicine (UM-MSoM), Miami, FL, USA.

Nature communications
|July 3, 2025
PubMed
概括

一种模仿BMP-7的THR-123在糖尿病小鼠中通过诱导胰腺管道的新岛形成来再生β细胞质量. 这表明了对胰岛素依赖糖尿病的新疗法.

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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