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免疫治疗早期HR+乳腺癌患者的动态单细胞系统免疫反应

Xiaopeng Sun¹, Margaret L Axelrod², Adrienne G Waks³

¹Cancer Biology Program, Vanderbilt University, Nashville, TN, USA.

NPJ breast cancer

|July 3, 2025

概括

周围免疫细胞的变化,包括细胞毒性CD8T细胞和B细胞和单细胞中的干扰素反应,可以预测接受新辅助纳布-帕克利塔塞尔加布罗利祖马布的激素受体阳性乳腺癌患者的治疗有效性.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

免疫检查点抑制剂 (ICI) 在乳腺癌中显示出有限的益处,因此需要生物标志物进行个性化治疗.
识别预测生物标志物对于优化激素受体阳性乳腺癌患者的治疗至关重要.

研究的目的:

在乳腺癌中识别外围血液预测生物标志物对新辅助剂纳布-帕克利塔塞尔加布罗利祖马布的反应.
在新辅助疗法期间监测周围免疫动态.

主要方法:

单细胞RNA测序和T细胞受体 (TCR) 测序28名患者的外周血液单核细胞.
对免疫细胞种群及其功能状态的分析.

主要成果:

响应的患者在治疗后显示了Granzyme B阳性 (GZMB+) 细胞毒性CD8T细胞的扩张和TCR克隆的变化.
没有反应的患者表现出T细胞耗尽的迹象,治疗引起的变化最小.
在B细胞和单细胞中的干扰素反应标志与治疗反应相关联.

结论:

外周免疫学特征可以作为动态抗瘤免疫反应的可访问指标.
这些发现可能有助于监测治疗疗效,并指导乳腺癌治疗决策.

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