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Updated: Sep 17, 2025

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
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在DDX1甲基化中介的MATR3拼接中,通过启动色素重编程来调节椎间盘退化

Dingchao Zhu1, Huaizhen Liang1, Bide Tong1

  • 1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Nature communications
|July 3, 2025
PubMed
概括

椎间盘退化 (IVDD) 导致腰部疼痛与通过EZH2.2的DDX1甲基化有关. 抑制EZH2或恢复MATR3-L表达可以治疗IVDD.

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