用户对长效暴露前预防在东部和南部非洲预防艾滋病毒的偏好:一个范围审查
Brian Pfau1, Arden Saravis2, Sarah N Cox2,3
1Department of Epidemiology, University of Washington, Seattle, WA, USA. bpfau@uw.edu.
BMC public health
|July 3, 2025
概括
在东部和南部非洲,长期作用的暴露前预防 (PrEP) 注射剂比每日服用的药片更受欢迎. 产品偏好各不相同,这凸显了需要多样化的艾滋病毒预防选择.
科学领域:
- 公共卫生 公共卫生
- 预防传染病 预防传染病
- 艾滋病毒/艾滋病研究研究
背景情况:
- 新的长效暴露前预防 (PrEP) 配方 (注射剂,植入物,戒指) 为预防艾滋病毒提供了每日服用药物的替代品.
- 东部和南部非洲 (ESA) 面临着最高的艾滋病毒负担,并在全球范围内拥有最大的PrEP覆盖范围.
- 了解ESA中对PrEP产品的用户偏好对于最大化吸收和公共健康益处至关重要.
研究的目的:
- 在ESA中对PrEP产品偏好进行范围审查.
- 在不同亚群中确定首选的长效PrEP配方.
- 确定影响该地区PrEP产品选择的因素.
主要方法:
- 在PubMed,Embase和会议摘要中进行了搜索 (2014-2024年).
- 包括评估在ESA中对长效或按需PrEP产品的偏好的研究.
- 综合了49项符合条件的研究的结论.
主要成果:
- 长效PrEP产品通常比口服药片更受青.
- 按需PrEP是首选而不是每日剂量;长效PrEP是首选而不是按需.
- 注射药物是各种亚种群中最喜欢的配方,其中持续时间,疗效和谨慎性是关键因素.
结论:
- 在ESA中,长效PrEP,特别是注射剂,比每日口服PrEP更受青.
- 由于对注射,副作用和污名的担忧,每月口服PrEP或植入物的子组偏好存在.
- 提供多种PrEP产品选择对于最大限度地覆盖并满足各种需求至关重要.
相关概念视频
01:10Retrovirus Life Cycles
46.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.9K
01:25Transmission-based Precautions II: Airborne and Protective Environment
1.5K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.5K
01:15Drug Dosage Regimen: Overview
3.8K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.8K