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怀孕结果使用辅助生殖技术在脏移植接受者的怀孕结果
Silvi Shah1, Brenna Rachwal1,2, Prema Vyas3
1Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH.
Transplantation
|July 4, 2025
概括
在移植患者使用辅助生殖技术 (ART) 的怀孕中,与自然受孕相比,高血压,早产和剖腹产的风险增加. 生产率和移植存活率保持相似.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生殖医学 生殖医学
- 移植手术 移植手术
背景情况:
- 不孕症影响了许多移植接受者.
- 移植后的怀孕会给母亲和胎儿带来很大的风险.
- 在这个人群中,辅助生殖技术 (ART) 怀孕的结果还不太清楚.
研究的目的:
- 为了研究和比较通过ART怀孕的脏移植接受者的怀孕结果,与自然怀孕相比.
- 在接受脏移植的妇女中确定与ART相关的特定风险和益处.
主要方法:
- 这是一项回顾性队列研究,利用了国际移植怀孕登记处的数据.
- 纳入标准:怀孕时14岁以上的移植接受者 (1968年3月至2022年7月).
- 后勤回归分析 (根据年龄,种族进行调整) 将ART与自然受孕结果进行比较.
主要成果:
- 在ART怀孕 (n=130) 中,高血压 (OR 1.57) 和剖腹产 (OR 1.60) 的调整几率较高.
- 在ART怀孕中,早产风险明显更高 (<37周,或2.07).
- ART导致出生体重和妊娠年龄的中位数较低,新生儿死亡率更高 (4.4%vs0.8%).
结论:
- 接受脏移植的人的ART怀孕与早产,高血压和剖腹产的风险增加有关.
- 在ART和自然受孕组之间,没有发现活产率或2年移植损失的显著差异.
- 虽然ART提供了怀孕的途径,但对脏移植接受者来说,仔细监测不良结果至关重要.
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