妊娠期间的日常尿液中阿尔多斯特分泌和摄入与幼儿时期的高正常血压有关
Hajir Al-Jorani1,2, Richard Christian Jensen1,3, Tina K Jensen3,4
1Department of Endocrinology Odense University Hospital Odense Denmark.
Journal of the American Heart Association
|July 4, 2025
概括
母亲的阿尔多和较高的摄入量与幼儿时期后代血压 (OBP) 的增加有关. 女孩更容易受到母亲摄入对OBP的影响.
科学领域:
- 生殖医学 生殖医学
- 儿科内分泌学 儿科内分泌学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 后代血压 (OBP) 可能受到产前编程的影响.
- 孕妇第三个月的阿尔多素水平与胎盘发育相关.
- 对于成年人的饮食建议包括高和低,以保持正常的功能.
研究的目的:
- 为了研究母体第三季度24小时尿液中阿尔多斯特水平与后代血压 (OBP) 之间的关联.
- 检查母亲的和摄入量对母亲的阿尔多和OBP之间的关系的影响.
主要方法:
- 在奥登斯儿童队列 (OCC) 中对475个母婴二进行前性研究.
- 从怀孕第29周收集的母体24小时尿液阿尔多斯特.
- 在多个时间点 (3,18个月,3,5年) 测量后代血压 (BP);从24小时尿液分泌中估计母亲的和摄入量.
主要成果:
- 母体阿尔多素升高与3个月和18个月后后代较高的缩血压相关.
- 增加母亲的摄入量 (1000 mg/d) 与5岁以下的后代较高的缩血压有关,特别是在女孩身上.
- 没有观察到母亲的摄入量和后代BP之间的显著联系.
结论:
- 增加的母体阿尔多素和更高的摄入量与幼儿时期的后代血压增加有关,尽管在正常范围内.
- 女孩似乎更容易受到母亲摄入对后代血压的影响.
- 研究结果表明,母亲的饮食和荷尔蒙因素在规划后代心血管健康方面可能发挥作用.
相关概念视频
Antihypertensive Drugs: Potassium-Sparing Diuretics
777
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
777
Hormonal Regulation
33.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.7K
Hypertension and Regulation of Blood Pressure
3.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.1K
Regulation of Sodium and Potassium
869
The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
869
Hypertension III: Clinical Manifestations and Diagnostic Studies
54
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
54
Hormonal Regulation of Blood Pressure
3.2K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
3.2K


