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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
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Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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相关实验视频

Updated: Sep 17, 2025

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
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IL-21有助于2型B型记忆细胞的形成.

Alexandra R Dvorscek1, Jesse Mulder1, Zhoujie Ding1

  • 1Department of Immunology, Monash University, Prahran, VIC, Australia.

Journal of immunology (Baltimore, Md. : 1950)
|July 4, 2025
PubMed
概括

介素-21 (IL-21) 对于2型B型记忆细胞 (mBC2) 的形成至关重要,这些细胞在过敏反应中至关重要. 它的缺乏会损害mBC2的发育,挑战其作为过敏抑制剂的使用.

关键词:
B 细胞 B 细胞 B 细胞Th2 Th2 的意思是什么?过敏是一种过敏.mBC2 是一个BC2 系统.记忆 记忆 记忆 记忆 记忆

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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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科学领域:

  • 免疫学 免疫学 免疫学
  • 过敏研究 研究过敏
  • 细胞生物学 细胞生物学

背景情况:

  • 2型记忆B细胞 (mBC2) 是IgE血细胞的关键前体,在过敏性疾病中起着关键作用.
  • 众所周知,中白素-21 (IL-21) 对一般B细胞分化至关重要,但其在mBC2形成中的具体作用尚不清楚.

研究的目的:

  • 研究IL-21信号传递在2型B型记忆细胞 (mBC2) 的发展中的作用.
  • 为了确定IL-21缺乏是否影响mBC2的产生和随后的抗体反应.

主要方法:

  • 使用IL-21受体缺乏 (IL-21R-/-) 的小鼠,用卵素免疫.
  • 分析B细胞种群,包括mBC2和生殖中心B细胞,使用流细胞计.
  • 评估了血细胞的生成和抗体的产生.

主要成果:

  • 与对照组相比,IL-21R-/-小鼠在免疫接种后一周内显示出卵胺特异性mBC2的数量减少.
  • 在IL-21R-/-小鼠中观察到前记忆B细胞退出和前记忆生殖中心B细胞积累的缺陷.
  • 在IL-21R-/-小鼠中的生殖中心迅速减弱,导致mBC2数量的减少和抑制IgG1血细胞的产生.

结论:

  • IL-21信号传递是2型记忆B细胞 (mBC2) 正常形成和维持所需的.
  • 这些发现表明IL-21不是适合泛过敏抑制剂的标,因为它在mBC2发育中起着至关重要的作用.