肺动脉高血压中NT-proBNP和BNP测试:临床治疗和远程监测
Charlotte Durrington1,2, Christian Battersby1, Laura Holt1
1Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
概括
对肺动脉高血压 (PAH) 患者的临床治疗点N终端脑性尿素前激素 (NT-proBNP) 测试是可靠的. 在邮寄样本中,NT-proBNP也稳定,支持远程监测PAH.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 生物标记分析 生物标记分析
背景情况:
- 大脑尿性 (BNP) 和BNP的N端前激素 (NT-proBNP) 是肺动脉高血压 (PAH) 的关键生物标志物.
- 及时的生物标志物结果对于临床评估至关重要,但往往会延迟.
- 调查NT-proBNP的临床检测 (POCT) 和邮寄样本的可靠性对于有效的PAH管理至关重要.
研究的目的:
- 在PAH患者中评估NT-proBNP和BNP临床检测 (POCT) 的可靠性.
- 通过邮件发送的血液样本中确定NT-proBNP的稳定性,用于远程监测.
- 为了比较NT-proBNP和BNP在PAH风险分层中的诊断准确度.
主要方法:
- 预期招募第一组PAH患者.
- 实验室和POCTNT-proBNP/BNP测量的比较.
- 在邮政样本中分析NT-proBNP稳定性和演习的影响.
- 阶级内相关系数 (ICC) 和通过巴布洛克回归用于协议评估.
主要成果:
- NT-proBNP POCT和实验室结果显示出极好的一致性 (ICC=0.97).
- 然而,BNP POCT和实验室结果显示不等价.
- 在邮政样本中,NT-proBNP显示出良好的一致性,不受炼的影响.
- NT-proBNP风险分层比BNP更为敏感.
结论:
- POCT NT-proBNP是临床PAH评估的可靠和可访问的替代方案.
- 从邮寄样本中进行的NT-proBNP分析显示,远程患者监测具有前景.
- 与BNP相比,NT-proBNP是PAH风险分层的一个更有效的生物标志物.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
222
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
222
Pulse rhythm
934
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
934
Pulmonary Function Tests
436
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
436
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
258
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
258
Pneumonia III: Complications and Assessment
452
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
452
Pre-Procedural Guidelines for Assessing Blood Pressure
633
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
633


