对环境与甲状腺功能之间的关联进行了批判性审查,这对潜在的神经发育影响有影响
N Karyakina1,2, N Shilnikova1,2, N Farhat3
1Risk Sciences International (RSI), Ottawa, Canada.
概括
(Mn) 暴露可能会影响甲状腺功能和神经发育,但目前的证据尚不确定. 需要更多的研究来了解Mn Mn.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 神经内分泌学神经内分泌学
背景情况:
- (Mn) 是一种必不可少的微量元素;然而,过度暴露在环境中可能会导致不良健康影响.
- 新出现的证据表明,暴露,甲状腺激素干扰和儿童潜在的神经发育问题之间存在联系.
研究的目的:
- 系统地审查和综合有关暴露与甲状腺不良影响之间关系的现有证据.
- 探索Mn诱导的甲状腺功能障碍对儿童神经发育结果的潜在影响.
主要方法:
- 对Medline,EMBASE和Scopus数据库进行系统的文献搜索.
- 纳入标准集中在调查暴露和甲状腺功能的研究上.
- 分析了31项符合条件的研究,包括17项人体研究和14项毒理学研究.
主要成果:
- 关于Mn对甲状腺功能的影响,来自人类研究的证据仍然没有确定性.
- 没有研究直接评估Mn在神经发育结果上的甲状腺介导作用.
- 动物研究表明,可能会影响甲状腺激素,但机制尚不清楚;会在甲状腺组织中积累.
结论:
- 目前的数据不足以确定暴露与甲状腺功能障碍或神经发育障碍之间的因果关系.
- 需要进一步的研究来阐明Mn对甲状腺和神经发育的潜在影响背后的生物机制.
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