柔软的可挤出的状颗粒与纳米结构的肌,用于局部粘附和药物释放到膀癌
Jin Gyun Lee1, Joseph Petraccione2, Katherine A Trese1
1Department of Chemical and Biological Engineering, University of Colorado Boulder, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Advanced materials (Deerfield Beach, Fla.)
|July 4, 2025
概括
研究人员开发了仿生软树突颗粒 (SDP) 用于膀癌药物输送. 这些颗粒粘附于癌细胞,使得药物持续释放和增强免疫反应,毒性最小.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 膀癌具有显著的死亡风险.
- 目前的静脉注射药物输送面临着在膀中药物保留不良的挑战.
- 现有的高表面积纳米材料制造方法复杂且昂贵.
研究的目的:
- 开发一个简单的,仿生药物输送平台,用于增强膀癌治疗.
- 创建软树突颗粒 (SDPs) 具有改善的粘附性和持续的药物释放能力.
- 评估SDPs在临床前膀癌模型中的有效性和安全性.
主要方法:
- 使用流体流模板制造,使用基托涂层制造的基于聚乳-co-glycolic 酸 (PLGA) 的 SDP.
- 在SDP中封装化疗剂 (gemcitabine,docetaxel,methotrexate) 在SDP中.
- 通过酸盐水凝给药SDPs,以控制沉积和释放.
- 在体外和体内评估SDP粘附,药物释放,细胞毒性和膀癌模型中的免疫反应.
主要成果:
- SDP 显示对小鼠和人类癌细胞的粘附时间长 (数天).
- SDPs有效地封装并释放了多种化疗药物,在体外显示出优异的癌细胞杀死.
- 在小鼠模型中,含有gemcitabine的SDP诱导了较强的CD45+免疫细胞反应,与对照组相比.
- 药物输送平台在体内表现出最小的毒性.
结论:
- 一种简单的生物模拟流体流量模板方法成功生产了用于膀癌治疗的粘合性SDP.
- 该SDP平台提供长时间保留和控制释放的化疗药物,增强治疗疗效.
- 这种多功能药物输送系统显示出改善表皮癌模型,特别是膀癌的治疗方法的前景.
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