人类细胞巨乳病毒在肝硬化患者中重新激活,急性失补偿
Changze Hong1, Zuxiong Huang2, Yingli He3
1Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Clinical and molecular hepatology
|July 4, 2025
概括
人类细胞巨乳病毒 (HCMV) 的重新激活在急性失补偿症 (AD) 患者中很常见,增加死亡率和ACLF风险. 建议在AD患者中对HCMV进行积极监测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 人类细胞巨乳病毒 (HCMV) 反激活对患有急性失补偿症 (AD) 肝硬化患者的结局的影响尚不清楚.
- 调查HCMV发病率及其与阿尔茨海默病患者肝脏结果的相关性对于患者管理至关重要.
研究的目的:
- 为了确定阿尔茨海默氏病患者中HCMV重新激活的发生率.
- 探索HCMV再激活和肝脏结果之间的关联,包括ACLF和死亡率.
主要方法:
- 分析了两个潜在的AD患者的多中心队列.
- 使用实时的定量聚合酶连锁反应检测出HCMV的重新激活在阳性人群中.
主要成果:
- 在两个队列中,AD患者的4.8%发生了HCMV的重新激活.
- HCMV的重新激活独立地与细菌感染,肝衰竭,ACLF发育和90天死亡率有关.
- 患有HCMV再激活和细菌感染的患者的预后较差;甘西克洛维尔治疗显示死亡率下降的趋势.
结论:
- 在阿尔茨海默病患者中,HCMV的重新激活很普遍,特别是那些患有细菌感染或肝衰竭的患者.
- 在AD患者中,HCMV复激活是ACLF和90天死亡率的独立预测因子.
- 在阿尔茨海默病患者中进行常规查HCMV感染是有必要的,以改善临床结果.
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