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口服大麻治疗塔克桑诱导的神经病变:试验性随机化安慰剂控制研究

Margaret Haney¹, Tse-Hwei Choo¹, Amy Tiersten²

¹Department of Psychiatry, Columbia University Irving Medical Center, New York State Psychiatric Institute, New York, New York, USA.

Cannabis and cannabinoid research

|July 4, 2025

概括

这项试点研究发现,与安慰剂相比,虽然口服大麻是可行的,并且可以很好地耐受高素诱导的外围神经病变 (TIPN) 疼痛,但它恶化了神经病变和睡眠结果. 对TIPN的大麻进行进一步研究是有必要的.

科学领域:

在瘤学瘤学.
神经学神经学
药理学药理学是指药理学的学科.

背景情况:

高诱导的周围神经病变 (TIPN) 是乳腺癌患者化学疗法的常见和衰弱的副作用,治疗选择有限.
临床前研究表明,D9-四大麻素 (THC) 和大麻素 (CBD) 的组合可以协同缓解TIPN症状.

研究的目的:

评估与安慰剂相比,在患有疼痛性TIPN的患者中,口服大麻 (100毫克CBD:5毫克THC,TID) 的可行性和耐受性.
在TIPN患者中进行口服大麻对疼痛,睡眠和神经病变的疗效的初步评估.

主要方法:

一项为期8周的双盲随机试点研究,涉及12名患有TIPN的女性.
参与者接受了口服大麻囊 (100毫克CBD:5毫克THC,TID) 或安慰剂.
每日在线问卷追踪疼痛,睡眠和药物使用情况;每周问卷评估神经病变.

主要成果:

这项研究是可行的,并且耐受性良好,所有参与者完成了试验,并在两组中要求降低剂量.
虽然疼痛,疼痛干扰,睡眠和功能健康的整体指标随着时间的推移而有所改善,但大麻显著恶化了神经病症评级.
与安慰剂相比,大麻还显著恶化了睡眠和疼痛干扰评级.

结论:

对TIPN进行口服大麻的双盲,安慰剂对照测试是可行的,并且在这个患者群体中耐受良好.
与安慰剂相比,尽管一些症状的整体改善,但这种剂量的口服大麻表明神经病变,睡眠和疼痛干扰的恶化.
这些发现强调了安慰剂对照在大麻研究中的重要性,并表明需要进一步研究TIPN的剂量范围.

关键词:

癌症癌症癌症癌症癌症在Cannabidiol中使用.医用大麻医用大麻医用大麻神经病变性疼痛是一种神经性疼痛.这是一种四化大麻醇 (tetrahydrocannabinol).

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