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相关概念视频

Anatomical Terminology01:20

Anatomical Terminology

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Knowledge of anatomy is essential to understand human biology and medicine. Anatomists and health care professionals use standard terminology to describe the human body with more precision and no ambiguity. Anatomical terms have mostly Greek and Latin-derived roots. Because these languages are rarely used in conversation, the meaning of words remains the same. Each term is made up of a root in between the prefixes and suffixes. The root of a term often refers to an organ, tissue, or condition,...
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Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

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It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
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Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

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The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
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Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
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相关实验视频

Updated: Sep 17, 2025

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts
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人体解剖学的空间地图 (SAHA):跨人类器官的多模式亚细胞分辨率参考.

Jiwoon Park1,2, Roberto De Gregorio1,3, Erika Hissong1,4

  • 1Weill Cornell Medicine, New York, NY, USA.

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|July 4, 2025
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概括

人体解剖学的空间地图 (SAHA) 是一个新的资源,以亚细胞分辨率绘制人体组织. 这本地图揭示了细胞和相互作用,有助于疾病研究和精准医学.

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科学领域:

  • 人类解剖学 人类解剖学
  • 空间生物学 空间生物学
  • 基因组学就是基因组学.

背景情况:

  • 了解人类组织组织对于疾病研究至关重要.
  • 现有的地图集缺乏多式联络,亚细胞分辨率数据.
  • 细胞和组织之间的空间关系是生物功能的关键.

研究的目的:

  • 创建第一个健康成年人组织的多式,亚细胞分辨率的参考地图.
  • 在多个器官系统中绘制保存和器官特定的细胞.
  • 为空间诊断和精准医学提供一个基础框架.

主要方法:

  • 空间转录组学,蛋白质组学和组织学在>1500万个来自>100个捐赠者的细胞中进行整合.
  • 使用CosMx SMI,10x Xenium,RNAscope,GeoMx DSP和单核RNA-seq. 的高分辨率分析.
  • 与结直肠癌和炎症性肠病数据集进行比较分析.

主要成果:

  • 在胃肠道和免疫组织中详细地绘制细胞.
  • 识别空间组织的细胞状态和罕见的适应性免疫群体.
  • 检测与疾病相关的空间干扰,包括密码脱差和免疫重塑.

结论:

  • 人体解剖学的空间地图 (SAHA) 为研究人类组织组织提供了前所未有的资源.
  • 萨哈可以检测与癌症和IBD等疾病相关的空间干扰.
  • 开放式可访问的数据支持探索,基准测试和机器学习,以推进精准医学.