炎症/SCFA 形状与口腔/肠道微生物组之间的联系:在患有ST段升高心肌梗塞的患者中进行的一项观察性研究
Luis A Constantino-Jonapa1, Oscar R Aguilar-Villegas1, Paulina Hernández-Ruiz1
1Unidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Current research in microbial sciences
|July 4, 2025
概括
这项研究揭示了急性心肌梗塞患者口腔微生物群的显著差异. 口腔细菌可能会影响肠道细菌和炎症,这表明针对两种微生物组的新预防策略.
科学领域:
- 微生物组研究的研究.
- 心血管疾病是什么心血管疾病
- 炎症 炎症是一种炎症.
背景情况:
- 急性心肌梗塞 (AMI) 是墨西哥的主要死亡原因.
- 微生物群失调有助于低度炎症,这是AMI的一个因素.
- 了解口腔和肠道微生物群的相互作用对于心血管健康至关重要.
研究的目的:
- 在ST段升高心肌梗塞 (STEMI) 患者的口腔 (OM) 和肠道微生物群 (GM) 与健康对照进行比较.
- 调查OM和GM之间的相互作用.
- 为了将微生物组成与炎症标志物和代谢物相关联.
主要方法:
- 牙斑块和便样本的16S rRNA测序.
- 气色谱-短链脂肪酸 (SCFA) 的质谱学.
- 流细胞计用于血清细胞因子分析.
主要成果:
- 在STEMI患者中,OM多样性发生变化,但GM结构没有变化.
- 在OM和GM中,STEMI患者和对照人群之间存在明显的微生物属差异.
- 同黄油酸和2甲基黄油酸在STEMI患者中升高,而异黄油酸在对照组中更高.
- 在SCFA,细胞因子和微生物组成之间发现了相关性.
- 网络分析表明,口腔细菌可能通过SCFA产生细菌影响转基因.
结论:
- 口腔微生物群的改变与STEMI有关.
- 口腔细菌可能会影响肠道微生物群和全身炎症.
- 针对口腔和肠道微生物群,以及炎症标志物和SCFA,显示出预防心肌梗塞的前景.
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