基线和心脏代谢指数的变化和发生心血管疾病在两个潜在的队列中的变化
Jiangtao Li1,2,3, Xiang Wei1,2,3
1Division of Cardiovascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
基线和心脏代谢指数 (CMI) 的变化都与较高的心血管疾病 (CVD) 风险有关. 随着时间的推移监测CMI对于有效的CVD预防策略至关重要.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在一般人群中,心脏代谢指数 (CMI) 和心血管疾病 (CVD) 风险之间的关联尚未得到充分证实.
- 以前的研究集中在基线CMI上,忽视了CMI随时间变化的影响.
研究的目的:
- 检查基线心脏代谢指数 (CMI) 和患心血管疾病 (CVD) 的风险之间的关系.
- 调查随着时间的推移CMI变化与发生心血管疾病 (CVD) 的风险之间的关联.
主要方法:
- 利用来自中国健康与退休纵向研究 (CHARLS) 和英国老龄纵向研究 (ELSA) 的前性队列数据.
- 通过总结基线和第二次调查的CMI值来计算CMI变化.
- 采用生存分析和受限制的立方螺纹模型来评估关联.
主要成果:
- 在CHARLS (HR 1.36) 和ELSA (HR 1.24) 两种情况下,较高的基线CMI三位数与心血管疾病风险增加有关.
- 较高的CMI变化 (三位数3与三位数1) 也与CHARLS (HR 1.53) 和ELSA (HR 1.41) 中较高的心血管疾病风险相关.
- 在CHARLS和ELSA分别观察到CMI和CVD风险之间的非线性和线性关系.
结论:
- 基线心脏代谢指数 (CMI) 和随时间的变化都是心血管疾病 (CVD) 风险的显著预测指标.
- 持续监测CMI对于在临床环境中积极预防CVD至关重要.
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