饮食中的多金属摄入量与糖尿病视网膜病变风险之间的关联:基于人口的研究
Chaohua Zhang1, Haiyang Peng2, Qin Lang3
1Department of Urinary Nephropathy Center, Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Frontiers in nutrition
|July 4, 2025
概括
摄入更多的食金属,特别是,可能会降低患有糖尿病的成年人患糖尿病视网膜病变 (DR) 的风险. 这一发现表明,某些金属在糖尿病管理中具有潜在的保护作用.
科学领域:
- 营养流行病学 营养流行病学
- 代谢学 代谢学 代谢学
- 眼科医生 眼科 眼科
背景情况:
- 糖尿病视网膜病变 (DR) 是患有糖尿病的成年人视力丧失的主要原因.
- 饮食因素越来越多地被认为是它们在控制糖尿病并发症中的作用.
- 饮食金属对DR风险的具体影响需要进一步调查.
研究的目的:
- 为了检查六种食金属摄入量与美国糖尿病成年人糖尿病视网膜病变 (DR) 的风险之间的关联.
- 确定可能影响DR风险的特定金属,并探索潜在的剂量反应关系.
主要方法:
- 分析了美国2822名糖尿病成年人的数据,这些数据来自2007-2016年国家健康和营养检查调查 (NHANES).
- 使用多变量逻辑回归,加权量子总和回归 (WQS) 和贝叶斯内核机器回归 (BKMR) 来评估关联.
- 用于剂量反应分析和调解分析探索机制的受限制立方支线 (RCS) 回归.
主要成果:
- 饮食中 (Zn) 摄入与DR风险显著负相关 (OR=0.53,p=0.003).
- WQS回归显示,饮食中合并的金属摄入量与DR风险 (OR=0.79,p=0.024) 之间存在负相关性,其中是主要贡献者 (36.4%).
- BKMR模型证实了组合金属摄入对DR的保护性关联,显示出最高的后部包含概率 (PIP=0.8574).
结论:
- 饮食金属的摄入量增加,特别是,与糖尿病美国成年人糖尿病视网膜病变的风险降低有关.
- 这些发现表明一种潜在的营养策略,涉及饮食金属用于DR预防或管理.
- 需要进一步的研究,以阐明饮食金属在糖尿病视网膜病变中的保护作用背后的生物机制.
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