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鼻癌患者中质子和光子治疗之间的患者报告结果:一个纵向队列研究

Ching-Nung Wu^1,2,3, Yu-Ming Wang^1,4,5,6, Wei-Chih Chen^2,3

¹School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Clinical and translational radiation oncology

|July 4, 2025

概括

与体积调节弧线疗法 (VMAT) 相比,强度调节质子疗法 (IMPT) 在鼻癌 (NPC) 治疗期间减少了口腔等口腔症状和难以打开口腔的困难. 需要进一步的研究来证实这些发现.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

鼻癌 (NPC) 的治疗通常涉及放射治疗.
患者报告的结果 (PROs) 对于评估治疗有效性和生活质量至关重要.
比较不同的放射治疗技术,如强度调制质子疗法 (IMPT) 和体积调制弧线疗法 (VMAT),对于优化患者护理至关重要.

研究的目的:

在NPC患者中比较IMPT和VMAT之间的患者报告结果 (PROs).
评估IMPT与VMAT对放射治疗期间和之后症状严重性的影响.

主要方法:

在2021年至2023年期间进行了前性队列研究.
新诊断的NPC患者 (n=101) 在七个时间点使用修改后的28项症状痛苦度量表进行评估.
线性混合模型用于分析急性阶段 (RT后长达一个月) 的症状变化.

主要成果:

接受IMPT的人 (n=65) 比接受VMAT的人 (n=36) 显示出更好的基线特征.
与VMAT相比,IMPT在RT第七周显著减少了"口腔"和"难以开口"症状.
在两个治疗组之间,没有观察到"口腔干燥"或与耳朵相关的症状的显著差异.

结论:

IMPT表明,在NPC的RT急性阶段,特定的与口腔有关的症状减少了.
这些发现表明IMPT的潜在好处,但基线差异需要谨慎的解释.
建议进行随机研究,以进一步验证IMPT在NPC治疗中的优势.

关键词:

强度调节的质子疗法强度调节的质子疗法.鼻癌是指鼻癌.口腔的口腔.症状困扰度量表的症状困扰度量表.卷度调节的弧线疗法是指体积调节的弧线疗法.

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