中老年和老年中国人残留胆固醇和心血管疾病的动态变化之间的关系:一项国家队列研究
Bin Zhang1, Dengfeng Ma1, Zhiqiang Pei2
1Department of Cardiology, Taiyuan City Central Hospital, Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, China.
Frontiers in cardiovascular medicine
|July 4, 2025
概括
升高的残留胆固醇 (RC) 在中国老年人中动态增加心血管疾病 (CVD) 风险. 监测RC变化对于预防CVD在这个人群中至关重要.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 公共卫生 公共卫生
背景情况:
- 基础残留胆固醇 (RC) 的升高是心血管疾病 (CVD) 的已知危险因素.
- 对RC的动态变化及其与心血管疾病风险的关联仍然不完全理解,特别是在多样化的人口中.
研究的目的:
- 研究残留胆固醇 (RC) 水平的动态变化与心血管疾病 (CVD) 的发生之间的关系.
- 评估RC动态对中年和老年中国人心血管疾病风险的预测价值.
主要方法:
- 一项使用中国健康和退休长度研究 (CHARLS) (2011年和2015年) 数据的队列研究.
- 包括4431名年龄≥45岁的参与者,具有完整的RC和CVD数据.
- K-means集群分析对RC变化进行了分类;物流回归和ROC曲线分析了心血管疾病风险关联.
主要成果:
- 在基线RC和CVD之间观察到线性关联.
- 与集群1相比,集群3的参与者 (较高的RC增加) 显示心血管疾病风险显著增加 (OR=1.69).
- 在基线病 (OR=15.34) 和RC变化与BMI之间的相互作用的参与者中,观察到更高的CVD风险.
结论:
- 动态增加的残留胆固醇 (RC) 水平是心血管疾病 (CVD) 风险升高的重要预测因素.
- 建议对RC水平波动进行持续监测,以便在中老年和老年中国人群中制定有效的心血管疾病风险降低策略.
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