怀孕期间母亲血压轨迹与低出生体重之间的关系:基于NHANES 2005-2006年的纵向研究
Huiqiang Liu1, Yanping Wei1, Wen Zhang1
1Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Frontiers in pediatrics
|July 4, 2025
概括
母亲血压轨迹显著影响新生儿出生体重. 怀孕期间高中压血压 (SBP) 轨迹增加了低出生体重 (LBW) 婴儿的风险.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 公共卫生 公共卫生
背景情况:
- 已知母亲血压的动态变化会影响新生儿的出生体重.
- 有限的研究已经研究了怀孕期间特定血压轨迹与低出生体重 (LBW) 风险之间的关联.
研究的目的:
- 根据三个产前测量,使用基于组的轨迹建模 (GBTM) 识别不同的孕产妇血压轨迹.
- 探索这些已识别的血压轨迹与LBW发生之间的关联.
主要方法:
- 使用了NHANES 2005-2006数据库,其中包括330名孕妇 (41例LBW病例).
- 应用GBTM来建模系统血压 (SBP),透气血压 (DBP) 和脉冲压 (PP) 的轨迹.
- 采用多层逻辑回归和定向非循环图 (DAG) 分析来评估关联和共变量选择.
主要成果:
- 确定了三个不同的母体血压轨迹模式.
- 与低血压轨迹相比,高中SBP轨迹与LBW风险增加显著相关 (OR = 4.479,P < 0.001).
- 这种关联在年长的母亲 (>40岁) 中,那些BMI>28的母亲中,收入较低,没有酒精消费,胆固醇异常中更强烈.
结论:
- 孕产妇的血压轨迹,特别是高中SBP,与LBW密切相关.
- 在怀孕期间监测血压波动至关重要.
- 针对母亲血压的早期干预可能有助于减少LBW的发生率.
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