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慢性病与需要治疗的抑郁症相关:一项回顾性队列研究
Andreas Kommer1, Paul Christoph Claßen1, Eva Maria Schleicher1
1Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Clinical kidney journal
|July 4, 2025
概括
患有慢性病 (CKD) 的患者患抑郁症的发生率更高. 这种增加的风险,特别是在年轻人中,需要临床意识和积极的心理健康管理策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 抑郁症是慢性病 (CKD) 患者常见的并发症.
- 慢性病相关的抑郁症会对生活质量,治疗坚持产生负面影响,并增加住院和死亡的风险.
- 关于CKD抑郁症发病率的大规模人口数据有限.
研究的目的:
- 评估慢性病 (CKD) 患者抑郁症的发生率.
- 为了比较CKD患者和匹配的非CKD个体之间的抑郁率.
- 评估CKD与抗抑郁药处方需求之间的关联.
主要方法:
- 使用IQVIATM疾病分析仪数据库进行回顾性队列研究.
- 倾向性得分匹配以创建可比的CKD和非CKD队列 (每人165,787人).
- 卡普兰-梅尔曲线和考克斯回归分析,以比较10年累积发病率的抑郁症和抗抑郁药处方.
主要成果:
- 抑郁症的10年发病率在CKD队列中为24.2%,而非CKD队列中为22.2% (P < .001).
- 与非CKD患者相比,CKD患者 (9.0%) 的抗抑郁药处方发生率明显高 (3.5%),危险比为2.63 (95% CI 2.51-2.75).
- 慢性瘤和抑郁症之间的关联在60岁以下的患者中最为明显 (HR 6.03).
结论:
- 慢性病 (CKD) 与需要药物治疗的抑郁症发病率中等增加有关.
- 管理CKD患者的医疗保健提供者,特别是年轻患者,应该认识到并解决抑郁症的高风险.
- 这项研究强调了在CKD人口中进行心理健康查和管理的重要性.
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