免疫性和天生的免疫力对高剂量和重复接种的修改mRNA与未修改mRNA的免疫力

Olivia Engstrand1,2, Gustav Joas1,2, Marcos C Miranda1,2

  • 1Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 171 76 Stockholm, Sweden.

概括

这项研究比较了 rhesus 的新型 mRNA 疫苗结构,发现虽然修改和未修改的 mRNA 疫苗都暂时激活了先天免疫细胞和细胞因子,但它们引起了类似的 gag 特定抗体和 T 细胞反应,指导了未来的疫苗开发.

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