患有AECOPD的老年患者的药物相关问题和药物干预实践:一项前性研究
Zengqing Ma1, Hongjun Shi1, Guojun Hong1
1Department of Pharmacy, Gaochun Hospital Affiliated to Jiangsu University, Nanjing, Jiangsu, China.
Frontiers in pharmacology
|July 4, 2025
概括
慢性阻塞性肺病 (AECOPD) 急性恶化老年患者经常出现与药物相关的问题 (DRPs). 临床药剂师的干预措施显著改善了这些高风险患者的药物安全性和护理质量.
科学领域:
- 老年医学 老年医学
- 临床药房 临床药房
- 肺部病理学 肺部病理学
背景情况:
- 患有AECOPD的老年患者容易患上与药物相关的问题 (DRPs),原因是生理储备减少和并发症.
- 这种脆弱性需要在这个人群中系统地识别和管理DRP.
研究的目的:
- 在老年AECOPD患者中识别和分类DRPs.
- 分析与这些DRP相关的原因和风险因素.
- 评估药物干预措施在解决DRPs方面的有效性.
主要方法:
- 在2023年1月至2024年12月期间住院的老年AECOPD患者的前性研究.
- 药物治疗药物使用欧洲药物护理网络 (PCNE) V9.1分类系统进行分类.
- 临床药剂师根据已识别的DRP原因实施了针对性的干预措施.
主要成果:
- 在544名AECOPD患者中观察到DRP发生率为55.15%,其中"P2治疗安全性"是最常见的类型 (45.04%).
- 多药性 (>15种药物) 和多种并发症 (>2) 是DRP的重要风险因素.
- 不适当的结果监测是DRP的主要原因,74.81%的DRP在药剂师干预后得到解决.
结论:
- 在中国住院的老年AECOPD患者中,DRPs的发病率很高.
- 伴随性疾病和处方药物的数量是DRPs的关键预测指标.
- 积极的临床药剂师参与改善了老年AECOPD患者的药物安全性,疗效和药物护理质量.
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