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在美国成年人中,TG/HDL-C比率与阻塞性睡眠呼吸暂停之间的相关性:一个横截面研究

Yanlin Yang¹, Gaohui Wu², Lingyun Ren²

¹Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Frontiers in neurology

|July 4, 2025

概括

甘油三和高密度脂蛋白胆固醇 (TG/HDL-C) 的比率比其他脂质标志物更好地预测阻塞性睡眠呼吸暂停 (OSA) 风险. 这种复合生物标志物有助于早期发现OSA并对相关并发症进行干预.

科学领域:

心血管健康心血管健康
代谢综合征是代谢综合征的一种.
睡眠医学睡眠医学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与失脂症,认知问题和心脏问题有关.
研究甘油与高密度脂蛋白胆固醇 (TG/HDL-C) 的比率作为OSA的生物标志物.
通过代谢调节探索TG/HDL-C在通过代谢调节来管理OSA并发症中的作用.

研究的目的:

评估TG/HDL-C比率在预测OSA患病率方面的有效性.
将TG/HDL-C的预测性能与传统的脂质指数进行比较.
检查TG/HDL-C在早期OSA检测中的临床实用性.

主要方法:

来自NHANES 2015-2018年全国代表性成年人队列 (n=3,270) 的分析.
权重多变量逻辑回归和非线性关联的受限立方线.
接收机操作特征 (ROC) 曲线分析,将TG/HDL-C与TG,HDL-C和NHHR进行比较.

主要成果:

在OSA和非OSA组之间发现了显著的脂质特征差异 (p < 0.001).
每个单位增加的TG/HDL-C与17%更高的OSA风险相关 (OR=1.17,p=0.045) 与非线性效应.
与NHHR (AUC=0.572) 相比,TG/HDL-C显示出更高的预测准确性 (AUC=0.589).
亚组分析显示,TG/HDL-C的预测值因家庭收入和心力衰竭/心血管炎患者而异.

结论:

TG/HDL-C比率是比TG和NHHR更有效地预测OSA风险的指标.
这种复合脂质指数为早期OSA识别提供了临床价值.
结果支持使用TG/HDL-C进行有针对性的干预,以减轻与OSA相关的风险.

关键词:

尼汉斯 (NHANES) 是一个名人.在TG/HDL-C上.一个横截面研究.脱脂血症是什么脱脂血症阻塞性睡眠呼吸暂停症是什么

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