概括
日本食品安全委员会评估了除草剂pentoxazone,在动物研究中发现了肝脏和膀的影响. 为了人类的安全,可接受的每日摄入量 (ADI) 设定为0.23 mg/kg bw/day.
科学领域:
- 农业化学 农业化学
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 托克萨 (CAS编号: 110956-75-7) 是一种oxazolidine的除草剂.
- 根据"农业化学品监管法"要求进行重新评估.
- 提交了关于牲畜命运,基因毒性和文献的数据.
研究的目的:
- 进行pentoxazone.zone的风险评估.
- 为了确定人类消费可接受的每日摄入量 (ADI).
主要方法:
- 基于提交的文件和附加数据的风险评估.
- 对牲畜 (山羊,) 和狗的毒性研究的评估.
- 对基因毒性,生育力和产性数据的分析.
主要成果:
- 观察到的主要不良反应:肝脏细胞增大和尿膀的增殖性病变.
- 没有发现对生育力或产性有不良影响.
- 最低的无观察不良影响水平 (NOAEL) 是1年的狗研究中的23.1 mg/kg bw/day.
结论:
- 托克萨对肝脏和膀构成风险.
- 没有发现生物学上显著的基因毒性.
- 使用100倍的安全因子确定了0.23 mg/kg bw/day的可接受每日摄入量 (ADI).
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