中老年和老年中国成年人的细颗粒物,体力活动和心血管疾病
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
BMJ open sport & exercise medicine
|July 4, 2025
概括
定期体力活动 (PA) 显著降低心血管疾病 (CVD) 的风险,即使长期暴露于细颗粒物 (PM2.5). 高的PA可以减轻PM2.5的风险.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 公共卫生 公共卫生
背景情况:
- 长期暴露于细颗粒物 (PM2.5) 是心血管疾病 (CVD) 的重要危险因素.
- 众所周知,体力活动 (PA) 对心血管有好处,但其与PM2.5暴露与心血管疾病风险相关的相互作用尚未完全理解.
研究的目的:
- 估计长期暴露于PM2.5和PA对心血管疾病风险的综合影响.
- 评估PA对心血管的益处是否超过PM2.5暴露的不良影响.
主要方法:
- 利用了来自中国健康与退休长度研究和中国高空气污染物的数据.
- 采用考克斯的比例危险模型来分析PA和PM2.5对心血管疾病的独立和联合影响.
- 进行了相互作用分析,以探索PM2.5和PA之间对心血管疾病风险的修改效应.
主要成果:
- 增加的PA与心血管疾病风险显著降低有关 (HR=0.90每IQR增加).
- 增加的PM2.5暴露与更高的心血管疾病风险有关 (HR=1.05每10μg/m3增加).
- 低PA和高PM2.5暴露的个体表现出最高的心血管疾病风险 (HR=1.56). 在低/中等PA组中,PM2.5增加了心血管疾病风险,但在高PA组中并非如此.
结论:
- 高水平的PA显示出减轻PM2.5暴露对心血管的有害影响的潜力.
- 氧化是一种有效的降低心血管疾病风险的策略,即使在PM2.5度较高的环境中也是如此.
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