与非糖尿病慢性病相关的血和尿液代谢物:HELIUS研究
Charlotte M Mosterd1,2, Barbara J H Verhaar1,3, Bert-Jan H van den Born1,3
1Department of Internal and Vascular medicine, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands.
Kidney medicine
|July 4, 2025
概括
尿中的代谢物,特别是脂质,是慢性病 (CKD) 的更强的预测因素,而不是血代谢物. 这些在非糖尿病病 (CKD) 中的发现在很大程度上转化为糖尿病病 (DKD),表明共享的疾病途径.
科学领域:
- 代谢学 代谢学 代谢学
- 生物标志物发现发现
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 慢性病 (CKD) 影响着各种人群,需要确定可靠的生物标志物.
- 区分非糖尿病性CKD和糖尿病性病 (DKD) 对于有针对性的治疗至关重要.
- 代谢物分析为了解病病理生理学提供了一个有希望的途径.
研究的目的:
- 为了确定非糖尿病性CKD的预测性血和尿液代谢物.
- 在DKD群体中验证这些已识别的生物标志物.
- 探索非糖尿病CKD和DKD之间潜在的共享代谢途径.
主要方法:
- 通过对血和尿液样本进行非向LC-MS/MS分析进行的横截面代谢组研究.
- 包括来自多民族队列的非糖尿病CKD,DKD和健康对照的参与者.
- 机器学习和物流回归模型的应用用于代谢物预测和关联分析.
主要成果:
- 与血代谢物相比,尿液代谢物对非糖尿病CKD的预测能力更高.
- 主要预测性血代谢物包括氨基酸 (例如,N-乙氨基酸,histidine) 和.
- 主要的预测性尿液代谢物是脂质,特别是基米林和脂胆.
结论:
- 尿中的代谢物概况在多民族人群中与CKD密切相关.
- 对非糖尿病性CKD的已识别的血和尿液代谢物的预测价值在很大程度上延伸到DKD.
- 这些发现表明,非糖尿病CKD和DKD都有一个共同的潜在病理生理学.
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