血清维生素D状况与极度肥胖成年人的心脏代谢风险因素之间的关联:一个横截面研究
Yan Zhou1, Chunyan Wang1, Zhixing Wang1
1Department of Endocrinology, Aviation General Hospital, Beijing, China.
International journal of endocrinology
|July 4, 2025
概括
维生素D缺乏症在中国极度肥胖的人群中很常见. 低维生素D水平与较高的BMI和较低的HDL-c/ApoA1相关,表明心血管风险增加.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 营养科学 营养科学
背景情况:
- 维生素D在葡萄糖和脂质新陈代谢中的作用受到争议.
- 目前对维生素D和心脏代谢标记物的研究是有限和不一致的.
研究的目的:
- 研究中国北部极度肥胖成年人中维生素D水平和心脏代谢标志物之间的关系.
- 在这个人群中评估血清25(OH) D和脂质配置文件之间的关联.
主要方法:
- 在中国北京对293名极度肥胖的成年人 (BMI > 35 kg/m2) 进行横截面研究.
- 测量血清25(OH) D,葡萄糖,胰岛素和脂质.
- 多重线性回归分析调整为混因素.
主要成果:
- 维生素D缺乏的高患病率 (81.2%) 血清中位数为12.88 ng/mL的血清25(OH) D.
- 25 (((OH) D水平与BMI和副甲状腺激素负相关.
- 经过调整后的分析显示了25(OH) D与HDL-c和ApoA1.1之间的正相关性.
结论:
- 维生素D缺乏症在极度肥胖的中国人中非常普遍.
- 缺乏与更高的BMI和更低的HDL-c/ApoA1有关,这表明与心血管风险的联系.
- 需要进一步的研究,包括前性研究和临床试验,以证实这些关联.
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