来自南洋的冷适应细菌中的抗生素耐药性模式和比较的基因组洞察力
Shikha Sharma1, Abhishek Chauhan2, Anuj Ranjan2
1Amity Institute of Environmental Sciences, Amity University, 201313 Noida, Uttar Pradesh, India.
Frontiers in bioscience (Elite edition)
|July 4, 2025
概括
抗生素耐药的细菌 Bacillus subtilis 在南大洋中被发现,这表明人类对偏远环境的潜在影响. 持续监测对于防止抗菌素耐药性 (AMR) 传播至关重要.
科学领域:
- 微生物学 微生物学
- 环境科学 环境科学
- 基因组学就是基因组学.
背景情况:
- 抗生素耐药性是一个日益严重的全球健康问题,影响所有环境.
- 全球各地都发现了抗菌素耐药的微生物,这凸显了这一问题的普遍性.
- 这项研究的重点是来自南大洋印度部门的细菌.
研究的目的:
- 为了确定来自南大洋的 Bacillus subtilis 的抗生素易感性.
- 通过全基因组测序,在这些隔离物中识别抗生素耐药性基因 (ARG).
- 通过比较基因组学研究ARG的全球分布和演变.
主要方法:
- 培养了细菌分离物,并使用阿加井扩散试验测试了它们对抗生素的敏感性.
- 采用全基因组测序来检测和识别特定的ARG.
- 比较基因组学分析了ARG分布在相关菌株和十年 (2014-2024) 期间.
主要成果:
- 细菌细菌分离物对甲尼达完全耐药,但对其他9种抗生素敏感.
- 确定了12种不同的ARG,包括那些通过流出,目标修饰和酶不活化产生抗药性的ARG.
- 菌株MB415携带了所有12个已识别的ARG,在相关菌株中分布不同.
结论:
- 在偏远的南大洋存在抗生素耐药B. subtilis表明可能的人类影响.
- 这些发现强调需要在原始海洋生态系统中持续监测AMR.
- 预防AMR的扩散和减轻AMR对生态的影响至关重要.
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