气溶通过高流量鼻和灵感同步小粒子振动网雾化器向成年模型输送气溶
Jie Li1, Osama Alanazi1,2, James B Fink1,3
1Department of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University, Chicago, Illinois, USA.
灵感同步振动网状雾化器 (VMNs) 在鼻子附近放置时,通过高流量鼻腔管 (HFNC) 改善气溶的输送. 小颗粒VMN在HFNC治疗期间增强吸入药物输送的承诺.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 高流量鼻腔管 (HFNC) 疗法被广泛用于呼吸辅助.
- 在HFNC期间优化气溶液药物输送对于治疗疗效至关重要.
- 之前的研究表明,在其他通风模式下,灵感同步振动网状雾化器 (VMN) 和小颗粒 VMN 改善了气溶的输送.
研究的目的:
- 评估灵感同步小颗粒VMN在HFNC期间喷雾剂输送的有效性.
- 为了比较灵感同步和连续VMN模式之间的气溶输送性能.
- 评估VMN放置 (加湿器入口与鼻腔管附近) 对吸入剂量的影响.
主要方法:
- 一个带有双腔肺模型的成年人体模型在HFNC期间模拟了自发呼吸.
- 在HFNC中使用的气流量为15,30和60L/分钟,温度为37°C.
- 小颗粒和传统的VMN在两个不同位置的灵感同步和连续模式下进行了测试,提供1毫升的阿尔布特罗尔.
主要成果:
- 吸入同步的VMN在靠近鼻腔管 (p <0.05) 放置时,总是提供比连续VMN更高的吸入剂量.
- 在加湿器进口处放置VMN显示出不同的结果,取决于流量和同步模式.
- 与常规VMN相比,在吸入同步模式下的小颗粒VMN在15和30L/分钟HFNC流量下增加了吸入剂量 (p < 0.05).
结论:
- 灵感同步的VMN在HFNC期间显著增加了吸入的气溶剂量,当它们位于鼻腔管附近时.
- 小颗粒VMN技术有可能进一步优化HFNC中的气溶输送.
- 最佳的VMN放置和同步对于最大限度地提高吸入药物输送至关重要.
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