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乳杆菌reuteri E9通过其代谢物GABA调节睡眠障碍
Yongcheng Jiang1, Lina Guo2, Houde He3
1Neurology Department, The People's Hospital of Chizhou, 247100 Chizhou, Anhui, China.
Frontiers in bioscience (Landmark edition)
|July 4, 2025
概括
乳杆菌reuteri E9作为一种精神生物,通过通过微生物群-肠-大脑轴促进抑制性神经递质和相关受体来改善睡眠. 这为睡眠障碍管理提供了一个非药物替代方案.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 失眠是一种普遍存在的睡眠障碍,具有有限的非成治疗方法.
- 微生物群-肠-大脑轴 (MGBA) 影响中枢神经系统的功能.
- 通过MGBA获得精神益处的精神生物,益生菌,显示出治疗前景.
研究的目的:
- 为了研究Lactobacillus reuteri E9作为治疗睡眠障碍的精神病菌的潜力.
- 评估L. reuteri E9对神经递质水平和与睡眠相关的基因表达的影响.
主要方法:
- 隔离和表征了一种非有毒的,耐药的乳酸菌菌株reuteri E9.
- 评估了E9在乙烯甲醇 (PTZ) 诱导的斑马鱼睡眠障碍模型中的影响.
- 分析了神经递质水平 (甘氨酸,胺,氨酸,GABA) 和GABA/黑素受体基因表达.
主要成果:
- L. reuteri E9显著上调抑制性神经递质 (GABA,牛素,甘氨酸,血清).
- E9在斑马鱼中表现出镇静作用,减少了和过度活跃.
- 在斑马鱼神经组织中,E9提高了GABA和黑激素受体基因表达的调节.
结论:
- 乳杆菌reuteri E9显示出作为治疗睡眠障碍的精神病菌的潜力.
- E9通过MGBA通路调节抑制性神经递质和睡眠受体表达.
- 这为传统的失眠治疗提供了一个非药物替代方案.
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