平均体积和自闭症谱系障碍的风险
Ülgen S Fideli1, Ann I Scher1, William W Young2
1Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
概括
儿童的平均体积 (MCV) 增加,但不是母亲,与更高的自闭症谱系障碍 (ASD) 风险有关. 这一发现表明,MCV可能是识别风险婴儿的早期生物标志物.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科医学 儿科医学 儿科医学
- 血液学 血液学 血液学
背景情况:
- 自闭症谱系障碍 (ASD) 诊断通常是在两岁后进行的.
- 目前,没有实验室测试可以在症状出现之前识别患有自闭症高风险的母亲或婴儿.
- 维生素B12和叶酸缺乏导致宏细胞性贫血,是已知的神经发育障碍的危险因素.
研究的目的:
- 为了研究增加的平均体积 (MCV) 和ASD诊断的可能性之间的关联.
- 为了确定母体或儿童的MCV水平是否与ASD的几率增加有关.
主要方法:
- 在母亲 (产前一年) 和儿童 (从出生到随访) 中评估的MCV值.
- 计算出母亲的平均MCV (mMCV) 和儿童的mMCV.
- 使用后勤回归模型来估计赔率比率和95%置信区间.
主要成果:
- 在出生前一年,母亲的MCV与儿童随后的ASD诊断没有关联.
- 在儿童中,较高的mMCV水平 (81 fL,84 fL,91 fL) 与ASD的几率增加有关 (分别为26%,38%,32%) 与76 fL的参考水平相比.
- 这项研究包括3798名母亲和9633名儿童.
结论:
- 增加的儿童MCV可以作为一种潜在的,廉价的生物标志物,用于识别患有自闭症风险的儿童.
- 这项探索性研究支持进一步调查MCV在早期发现发育障碍方面的临床实用性.
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