用维生素D补充剂预防结核病:一个元分析
Sheng Liu1, Tianyu Lin1, Yanyu Pan1
1The Second Department of Infection, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, Fujian Province, China.
Biomolecules & biomedicine
|July 4, 2025
概括
补充维生素D并不能显著预防结核病感染或疾病进展. 这次系统性审查没有发现任何保护作用,尽管维生素D在参与者中是安全的,并且能很好地容忍.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- 维生素D对免疫功能至关重要,这表明它可能在预防结核病 (TB) 中发挥作用.
- 关于维生素D对结核病的疗效的现有临床证据是不一致的.
研究的目的:
- 系统地审查和元分析随机对照试验 (RCT).
- 评估维生素D补充剂对预防结核病感染和进展为活跃疾病的影响.
主要方法:
- 搜索了主要的数据库 (PubMed,Embase,Cochrane,Web of Science) 在2025年1月之前.
- 包括与参与者在基线无活跃结核病的RCT.
- 使用随机效应模型计算聚合概率比率 (ORs),并使用GRADE评估证据确定性.
主要成果:
- 分析了6个RCT (15,677名参与者).
- 维生素D补充剂没有显著降低结核病感染风险 (OR:0.95;95% CI:0.79-1.14) 或进展到活性结核病 (OR:0.77;95% CI:0.56-1.05).
- 证据确定性中等;在不良事件中没有发现显著差异.
结论:
- 补充维生素D似乎没有显著降低结核病感染或疾病的风险.
- 在结核病预防研究中,维生素D补充剂是安全的,耐受性良好.
- 可能需要进一步的研究来澄清维生素D在特定人群或环境中的作用.
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