在心力衰竭的成年人中,血脑屏障功能障碍
Bhaswati Roy1, Xingfeng Shao2, Kamlesh J Jobanputra3
1Department of Anesthesiology, University of California Los Angeles, Los Angeles, California, USA.
概括
心力衰竭 (HF) 患者表现出血脑屏障 (BBB) 功能受损,导致脑组织损伤并影响认知和情绪调节. 解决BBB功能障碍对于改善高频率患者的大脑健康至关重要.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 放射学 放射学是指放射学
背景情况:
- 心力衰竭 (HF) 与大脑组织损伤有关,影响自主,认知和情绪功能,增加患者的发病率和死亡率.
- 在HF中脑损伤的确切病理机制尚不清楚,血脑屏障 (BBB) 功能障碍是潜在的贡献者.
研究的目的:
- 与健康对照组相比,研究心力衰竭 (HF) 患者的血脑屏障 (BBB) 完整性和功能.
- 探索BBB功能障碍,大动脉完整性和高频率患者的认知和情绪障碍之间的关系.
主要方法:
- 扩散权重伪连续动脉旋转标记 (DW-pCASL) 核磁共振被用于27名高压患者和59名对照人群.
- 通过BBB (Kw) 量化了动脉过渡时间 (ATT) 和水交换率,分别评估大动脉完整性和BBB功能.
- 认知功能,焦虑和抑郁症状被评估并与MRI发现相关联.
主要成果:
- 与对照组相比,HF患者表现出明显较差的认知能力和增加的情绪缺陷.
- 在HF患者中,在参与认知和情绪调节的多个大脑区域观察到Kw和ATT值的变化.
- 具体来说,在胰岛,海马和小脑中发现了Kw的增加,而ATT的变化在不同大脑区域之间有所不同.
结论:
- 心力衰竭与血脑屏障 (BBB) 功能受损和大动脉完整性的改变有关.
- 这些BBB变化可能会导致大脑区域的神经损伤,这些区域调节自主,情绪和认知功能.
- 针对BBB修复的治疗策略是有必要的,以减轻神经损伤和改善HF患者的大脑功能.
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