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中间纵向囊缺发在自由水上纠正MR扩散背后的语言障碍在自闭症中

Doudou Cao¹, Litong Ni¹, Qi Qi¹

¹Department of Radiology, First Medical Center, Chinese PLA General Hospital, Beijing, China.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

|July 4, 2025

概括

患有自闭症谱系障碍 (ASD) 的儿童中部纵向 (MdLF) 的发育变化与语言障碍有关. 早期评估MdLF微结构完整性对于理解与ASD相关的语言缺陷至关重要.

科学领域:

神经成像是一种神经成像.
发育神经科学的发展神经科学.
自闭症谱系障碍研究研究

背景情况:

中间纵向 (MdLF) 是腹腔语言网络中一个关键的白质通道.
在自闭症谱系障碍 (ASD) 中MdLF的作用及其发育轨迹仍未得到充分研究.

研究的目的:

研究ASD儿童中MdLF的微结构发展.
确定MdLF的变化是否有助于ASD儿童的语言障碍.

主要方法:

扩散核磁共振扫描用于重建57名患有自闭症儿童的MdLF和37名典型发育 (TD) 控制组 (4-9岁) 的MdLF.
用自闭症行为检查表来评估语言障碍.
一般线性模型和部分相关性分析了与年龄相关的差异和扩散指标和语言障碍之间的相关性.

主要成果:

对于MdLF分数异性质组织 (FA extsubscript{t}) 和轴性扩散性组织 (AD extsubscript{t}) 观察到显著的年龄组相互作用.
在ASD中,较低的FA extsubscript{t}和AD extsubscript{t}与较大的语言障碍相关.
右侧MdLF的更高的辐射扩散性组织也与ASD的语言障碍相关.

结论:

MdLF显示了ASD学龄前儿童的异常发育模式.
MdLF微结构完整性与ASD中的语言缺陷有关.
这些发现强调了MdLF在ASD相关语言困难中的重要性以及早期评估的必要性.

关键词:

自闭症谱系障碍自闭症谱系障碍语言语言语言语言语言语言.中间的纵向带.路径学路径学路径学路径学路径学白质是白色物质的组成部分.

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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

Language and Cognition

Language and Cognition

Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.