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Updated: Sep 17, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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炎症体传感器NLRP3与REV7相互作用,通过同源重组保持基因组完整性

Delphine Burlet1,2,3,4, Md Muntaz Khan1,2,3,4, Sabine Hacot1,2,3,4

  • 1INSERM U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France.

Nucleic acids research
|July 4, 2025
PubMed
概括

炎症体传感器NLRP3促进DNA修复途径的选择,以保持基因组的稳定性. 虽然NLRP3缺乏会损害同源重组,增加对PARP抑制剂的敏感性,但REV7损失会恢复这种修复途径.

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