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Updated: Sep 17, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Substrate Generation for Endonucleases of CRISPR/Cas Systems

Published on: September 8, 2012

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在桥螺旋环区域的结构完整性和侧链相互作用调节Cas9基底歧视

Difei Wu1, Sydney Snead2, Chhandosee Ganguly2

  • 1Department of Chemistry, University of Southern California, Los Angeles, CA 90089, United States.

Nucleic acids research
|July 4, 2025
PubMed
概括

了解CRISPR-Cas9的DNA向需要研究其桥螺旋 (BH) 的结构变化. 单导向RNA结合会诱导野生类型和Cas9蛋白的BH转移,影响DNA裂变.

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Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter06:59

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

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