葡萄糖皮质醇戒断综合征:使用VigiBase数据对病例的不成比例分析
Lütfi Mangal1, Burcu Eda Arda2, Hande Sipahi2
1Faculty of Pharmacy, Department of Toxicology, Yeditepe University, Istanbul, Turkey. ltfmngl@hotmail.com.
葡萄糖皮质醇戒断综合征 (GWS) 的风险在皮和贝他美时是最高的,特别是当局部使用时. 医疗保健提供者应向患者咨询与突然停用葡萄糖皮质激素相关的风险.
科学领域:
- 药物监督 药物监督 药物监督
- 内分泌学 在内分泌学.
- 药品安全 药品安全
背景情况:
- 葡萄糖皮质类药物被广泛使用,但与戒断综合征有关.
- 与严重戒断相关的特定葡萄糖皮质激素类型和注射途径尚不清楚.
研究的目的:
- 确定具有显著的药监警示信号的葡萄糖皮质类药物,以便撤销.
- 通过比较不同类型的葡萄糖皮质激素和施用途径的风险.
- 确定葡萄糖皮质醇戒断综合征 (GWS) 的人口和区域差异.
主要方法:
- 对2013年1月至2023年12月GWS的VigiBase报告的分析.
- 提取有关地区,严重程度,年龄,性别和适应症的数据.
- 计算报告赔率比率 (ROR) 来评估退出信号.
主要成果:
- 皮质 (ROR:4.04) 和贝他美 (ROR:3.81) 显示出与GWS的相关性最高.
- 局部给药常见的是皮和贝他美沙;口服的普雷尼松;静脉注射的甲基普雷尼索隆.
- 在女性 (60%) 和18-44岁年龄组 (36%) 中,GWS更为普遍;77%的病例是严重的.
结论:
- 突然停止使用葡萄糖皮质类药物可以导致GWS.
- 局部使用的皮和贝他美,局部/鼻腔使用的氨和口服/局部使用的皮需要对患者进行仔细的咨询.
- 提高意识和患者教育对于更安全的葡萄糖皮质醇处方实践至关重要.
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